Drug interactions
Betaxolol + Bismuth subsalicylate
Severity: Moderate
Betaxolol and Bismuth subsalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylate from bismuth subsalicylate may blunt the antihypertensive effect of betaxolol by reducing renal prostaglandin synthesis and promoting fluid retention. The effect is mostly relevant with repeated or high doses.
What this interaction means in plain words
Betaxolol and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Bismuth subsalicylate belongs to Gastrointestinal Tract.
Why it happens
Salicylate inhibits prostaglandin synthesis, causing sodium and fluid retention that opposes the antihypertensive effect.
What to do
Keep bismuth subsalicylate use short and monitor blood pressure if used repeatedly. Consider alternative therapy for prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Major
- Bismuth subsalicylate + Warfarin Major
- Acetylsalicylic acid + Bismuth subsalicylate Moderate
- Amlodipine-benazepril + Bismuth subsalicylate Moderate
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderate
- Aspirin rectal + Bismuth subsalicylate Moderate
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Betaxolol and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylate from bismuth subsalicylate may blunt the antihypertensive effect of betaxolol by reducing renal prostaglandin synthesis and promoting fluid retention. The effect is mostly relevant with repeated or high doses.
How serious is the interaction between Betaxolol and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep bismuth subsalicylate use short and monitor blood pressure if used repeatedly. Consider alternative therapy for prolonged use.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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