Drug interactions
Betaxolol + Etrasimod
Severity: Moderate
Betaxolol and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause transient heart rate reduction and AV conduction delay when started. Combined with betaxolol, bradycardia and conduction effects could be additive, although stable beta-blocker use did not show additive effects on heart rate.
What this interaction means in plain words
Betaxolol and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive negative chronotropic and dromotropic effects via S1P receptor modulation and beta-blockade.
What to do
Obtain a baseline ECG before starting etrasimod in patients on betaxolol and monitor heart rate. Seek cardiology advice if conduction abnormalities exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Betaxolol with Etrasimod?
MediHelp rates the interaction as moderate. Betaxolol and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can cause transient heart rate reduction and AV conduction delay when started. Combined with betaxolol, bradycardia and conduction effects could be additive, although stable beta-blocker use did not show additive effects on heart rate.
How serious is the interaction between Betaxolol and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting etrasimod in patients on betaxolol and monitor heart rate. Seek cardiology advice if conduction abnormalities exist.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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