Drug interactions
Betaxolol + Ibuprofen
Severity: Moderate
Betaxolol and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular ibuprofen use can reduce the antihypertensive effect of betaxolol, leading to higher blood pressure. This is most relevant with sustained NSAID use.
What this interaction means in plain words
Betaxolol and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduced vasodilation, opposing beta blocker effects.
What to do
Monitor blood pressure when ibuprofen is started or stopped and adjust antihypertensive therapy if needed. Consider paracetamol for long-term analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Ibuprofen?
MediHelp rates the interaction as moderate. Betaxolol and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular ibuprofen use can reduce the antihypertensive effect of betaxolol, leading to higher blood pressure. This is most relevant with sustained NSAID use.
How serious is the interaction between Betaxolol and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ibuprofen is started or stopped and adjust antihypertensive therapy if needed. Consider paracetamol for long-term analgesia.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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