Drug interactions
Betaxolol + Primidone
Severity: Moderate
Betaxolol and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is partly converted to phenobarbital, which induces hepatic enzymes and may reduce levels of betaxolol. The beta-blocker effect may be weaker.
What this interaction means in plain words
Betaxolol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Enzyme induction by primidone and its metabolite phenobarbital increases betaxolol metabolism.
What to do
Monitor heart rate and blood pressure when primidone is started or stopped. Adjust the betaxolol dose to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Betaxolol with Primidone?
MediHelp rates the interaction as moderate. Betaxolol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is partly converted to phenobarbital, which induces hepatic enzymes and may reduce levels of betaxolol. The beta-blocker effect may be weaker.
How serious is the interaction between Betaxolol and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when primidone is started or stopped. Adjust the betaxolol dose to clinical response.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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