Drug interactions
Primidone + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Contraindicated
Primidone and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and acts as an enzyme and P-gp inducer. It is expected to substantially lower exposure of the HCV drugs and risks treatment failure.
What this interaction means in plain words
Primidone and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Primidone belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Primidone and its metabolite phenobarbital induce CYP3A4 and P-gp, which increases clearance of the HCV drugs.
What to do
Do not coadminister; use a non-inducing anticonvulsant, or defer HCV therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort Contraindicated
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
- Amitriptyline + Primidone Major
Frequently asked questions
Can I take Primidone with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Primidone and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Primidone is metabolized to phenobarbital and acts as an enzyme and P-gp inducer. It is expected to substantially lower exposure of the HCV drugs and risks treatment failure.
How serious is the interaction between Primidone and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-inducing anticonvulsant, or defer HCV therapy.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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