Drug interactions
Betaxolol + Salmeterol
Severity: Moderate
Betaxolol and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betaxolol is a beta-1 selective blocker that can blunt the bronchodilator effect of salmeterol. Selectivity is relative, so bronchospasm may occur in patients with asthma or COPD.
What this interaction means in plain words
Betaxolol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors.
What to do
Monitor respiratory status and bronchodilator response, and use the lowest effective betaxolol dose. Prefer an alternative to beta-blockade in patients with significant airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Salmeterol?
MediHelp rates the interaction as moderate. Betaxolol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Betaxolol is a beta-1 selective blocker that can blunt the bronchodilator effect of salmeterol. Selectivity is relative, so bronchospasm may occur in patients with asthma or COPD.
How serious is the interaction between Betaxolol and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and bronchodilator response, and use the lowest effective betaxolol dose. Prefer an alternative to beta-blockade in patients with significant airway disease.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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