Drug interactions
Betrixaban + Erythromycin
Severity: Moderate
Betrixaban and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits P-glycoprotein, which is responsible for betrixaban efflux, so betrixaban exposure increases. This raises the risk of bleeding.
What this interaction means in plain words
Betrixaban and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition by erythromycin reduces betrixaban efflux and increases systemic exposure.
What to do
Reduce betrixaban to 80 mg once as the initial dose, then 40 mg once daily during coadministration with a P-gp inhibitor. Monitor for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Frequently asked questions
Can I take Betrixaban with Erythromycin?
MediHelp rates the interaction as moderate. Betrixaban and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits P-glycoprotein, which is responsible for betrixaban efflux, so betrixaban exposure increases. This raises the risk of bleeding.
How serious is the interaction between Betrixaban and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to 80 mg once as the initial dose, then 40 mg once daily during coadministration with a P-gp inhibitor. Monitor for signs of bleeding.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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