Drug interactions
Betrixaban + Flurbiprofen
Severity: Major
Betrixaban and Flurbiprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a factor Xa inhibitor increases the risk of bleeding, including gastrointestinal hemorrhage. The risk is greater in older patients and those with renal impairment.
What this interaction means in plain words
Betrixaban and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: betrixaban inhibits factor Xa while flurbiprofen inhibits platelet function and damages gastric mucosa.
What to do
Avoid NSAIDs where possible and use paracetamol for analgesia. If unavoidable, use the lowest dose for the shortest time and monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Betrixaban with Flurbiprofen?
MediHelp rates the interaction as major. Betrixaban and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an NSAID with a factor Xa inhibitor increases the risk of bleeding, including gastrointestinal hemorrhage. The risk is greater in older patients and those with renal impairment.
How serious is the interaction between Betrixaban and Flurbiprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use paracetamol for analgesia. If unavoidable, use the lowest dose for the shortest time and monitor for bleeding and hemoglobin.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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