Drug interactions
Betrixaban + Ibuprofen
Severity: Major
Betrixaban and Ibuprofen: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise bleeding risk, and ibuprofen can also injure the gastric mucosa. Combined use increases the chance of gastrointestinal and other clinically significant bleeding.
What this interaction means in plain words
Betrixaban and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Betrixaban inhibits factor Xa while ibuprofen inhibits platelet function and damages the gastrointestinal mucosa, giving additive bleeding risk.
What to do
Avoid concurrent NSAID use where possible and choose paracetamol for pain. If unavoidable, monitor for signs of bleeding and check hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Betrixaban with Ibuprofen?
MediHelp rates the interaction as major. Betrixaban and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise bleeding risk, and ibuprofen can also injure the gastric mucosa. Combined use increases the chance of gastrointestinal and other clinically significant bleeding.
How serious is the interaction between Betrixaban and Ibuprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use where possible and choose paracetamol for pain. If unavoidable, monitor for signs of bleeding and check hemoglobin.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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