Drug interactions
Betrixaban + Nicardipine
Severity: Major
Betrixaban and Nicardipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betrixaban is a P-gp substrate, and P-gp inhibitors increase its exposure and bleeding risk. Nicardipine can inhibit P-gp, so betrixaban levels may rise.
What this interaction means in plain words
Betrixaban and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
P-gp inhibition by nicardipine decreases betrixaban efflux and increases systemic exposure.
What to do
Use the labeled reduced betrixaban regimen (80 mg once, then 40 mg daily) with P-gp inhibitors. Monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Betrixaban with Nicardipine?
MediHelp rates the interaction as major. Betrixaban and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Betrixaban is a P-gp substrate, and P-gp inhibitors increase its exposure and bleeding risk. Nicardipine can inhibit P-gp, so betrixaban levels may rise.
How serious is the interaction between Betrixaban and Nicardipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the labeled reduced betrixaban regimen (80 mg once, then 40 mg daily) with P-gp inhibitors. Monitor for bleeding.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Cobicistat. The full list is on the Nicardipine page.
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