Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Nicardipine
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Nicardipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a second dihydropyridine calcium channel blocker, so combining it with amlodipine duplicates therapy and increases the risk of hypotension, reflex tachycardia, flushing, headache and peripheral edema without added benefit. Nicardipine also inhibits CYP3A4 and may modestly raise amlodipine levels.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade produces additive vasodilation, with possible CYP3A4 inhibition by nicardipine.
What to do
Avoid using two dihydropyridine calcium channel blockers together and stop one of them. Monitor blood pressure and heart rate if overlap occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Nicardipine?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nicardipine is a second dihydropyridine calcium channel blocker, so combining it with amlodipine duplicates therapy and increases the risk of hypotension, reflex tachycardia, flushing, headache and peripheral edema without added benefit. Nicardipine also inhibits CYP3A4 and may modestly raise amlodipine levels.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Nicardipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two dihydropyridine calcium channel blockers together and stop one of them. Monitor blood pressure and heart rate if overlap occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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