Drug interactions
Betrixaban + Nilotinib
Severity: Moderate
Betrixaban and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein, which can raise betrixaban concentrations and bleeding risk.
What this interaction means in plain words
Betrixaban and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-gp inhibition by nilotinib reduces betrixaban efflux and increases exposure.
What to do
Use the reduced betrixaban dose recommended in labeling for P-gp inhibitors. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Betrixaban with Nilotinib?
MediHelp rates the interaction as moderate. Betrixaban and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein, which can raise betrixaban concentrations and bleeding risk.
How serious is the interaction between Betrixaban and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced betrixaban dose recommended in labeling for P-gp inhibitors. Monitor for bleeding.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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