Drug interactions
Betrixaban + Quinine
Severity: Moderate
Betrixaban and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits P-glycoprotein, which limits betrixaban efflux, so betrixaban exposure may increase. This raises the risk of bleeding.
What this interaction means in plain words
Betrixaban and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition by quinine increases betrixaban absorption and reduces its efflux.
What to do
Reduce betrixaban to the labeled lower-dose regimen for use with P-gp inhibitors. Monitor for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Betrixaban with Quinine?
MediHelp rates the interaction as moderate. Betrixaban and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits P-glycoprotein, which limits betrixaban efflux, so betrixaban exposure may increase. This raises the risk of bleeding.
How serious is the interaction between Betrixaban and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to the labeled lower-dose regimen for use with P-gp inhibitors. Monitor for signs of bleeding.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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