Drug interactions
Betrixaban + Sunitinib
Severity: Moderate
Betrixaban and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betrixaban is a P-gp substrate and exposure rises when P-gp is inhibited. Higher betrixaban levels increase bleeding risk, and sunitinib itself also has bleeding effects.
What this interaction means in plain words
Betrixaban and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux by sunitinib increases betrixaban absorption and exposure.
What to do
Reduce betrixaban to the labeled lower dose when used with a P-gp inhibitor and monitor for bleeding. Use another anticoagulant if the interaction is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Betrixaban with Sunitinib?
MediHelp rates the interaction as moderate. Betrixaban and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Betrixaban is a P-gp substrate and exposure rises when P-gp is inhibited. Higher betrixaban levels increase bleeding risk, and sunitinib itself also has bleeding effects.
How serious is the interaction between Betrixaban and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to the labeled lower dose when used with a P-gp inhibitor and monitor for bleeding. Use another anticoagulant if the interaction is a concern.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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