Drug interactions
Betrixaban + Tolmetin
Severity: Major
Betrixaban and Tolmetin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betrixaban is an anticoagulant, and NSAIDs add antiplatelet effects and gastrointestinal mucosal injury, increasing the risk of serious bleeding.
What this interaction means in plain words
Betrixaban and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: factor Xa inhibition plus NSAID platelet inhibition and GI mucosal damage.
What to do
Avoid concurrent NSAID use if possible; if unavoidable, use the lowest dose briefly with gastroprotection. Monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Betrixaban with Tolmetin?
MediHelp rates the interaction as major. Betrixaban and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Betrixaban is an anticoagulant, and NSAIDs add antiplatelet effects and gastrointestinal mucosal injury, increasing the risk of serious bleeding.
How serious is the interaction between Betrixaban and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use if possible; if unavoidable, use the lowest dose briefly with gastroprotection. Monitor for bleeding and hemoglobin.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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