Drug interactions
Bexagliflozin + Glibenclamide
Severity: Moderate
Bexagliflozin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors lower glucose independently of insulin, and combined with sulfonylureas they increase the risk of hypoglycemia. The risk is greatest with higher sulfonylurea doses.
What this interaction means in plain words
Bexagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive glucose-lowering from insulin secretion and urinary glucose excretion.
What to do
Consider reducing the glyburide dose when starting bexagliflozin and monitor for hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
- Bexagliflozin + Glipizide Moderate
Frequently asked questions
Can I take Bexagliflozin with Glibenclamide?
MediHelp rates the interaction as moderate. Bexagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors lower glucose independently of insulin, and combined with sulfonylureas they increase the risk of hypoglycemia. The risk is greatest with higher sulfonylurea doses.
How serious is the interaction between Bexagliflozin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting bexagliflozin and monitor for hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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