Drug interactions
Bexagliflozin + Gliclazide
Severity: Moderate
Bexagliflozin and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors combined with insulin secretagogues such as gliclazide raise the risk of hypoglycemia. The glucose-lowering effects are additive.
What this interaction means in plain words
Bexagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Gliclazide belongs to Endocrine.
Why it happens
Additive glucose lowering: urinary glucose excretion plus stimulated insulin secretion.
What to do
Consider reducing the gliclazide dose when starting bexagliflozin, and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
- Bexagliflozin + Glipizide Moderate
- Bexagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Bexagliflozin with Gliclazide?
MediHelp rates the interaction as moderate. Bexagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors combined with insulin secretagogues such as gliclazide raise the risk of hypoglycemia. The glucose-lowering effects are additive.
How serious is the interaction between Bexagliflozin and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the gliclazide dose when starting bexagliflozin, and monitor blood glucose.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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