Drug interactions
Bexarotene + Glimepiride-pioglitazone
Severity: Moderate
Bexarotene and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene may increase insulin sensitivity, which can add to the effect of glimepiride and pioglitazone and cause hypoglycemia. Bexarotene is also a lipid-raising agent, which is relevant to cardiovascular risk in diabetic patients.
What this interaction means in plain words
Bexarotene and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Bexarotene activates retinoid X receptors, partners of PPAR-gamma, which may add to the insulin-sensitizing effect of pioglitazone.
What to do
Monitor blood glucose closely when bexarotene is started. Reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Bexarotene and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene may increase insulin sensitivity, which can add to the effect of glimepiride and pioglitazone and cause hypoglycemia. Bexarotene is also a lipid-raising agent, which is relevant to cardiovascular risk in diabetic patients.
How serious is the interaction between Bexarotene and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when bexarotene is started. Reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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