Drug interactions
Bexarotene + Griseofulvin
Severity: Moderate
Bexarotene and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolized by CYP3A4, and griseofulvin may lower its concentrations. This could reduce antitumor effect in cutaneous T-cell lymphoma.
What this interaction means in plain words
Bexarotene and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Griseofulvin belongs to Anti Fungals.
Why it happens
CYP3A4 induction by griseofulvin increases bexarotene clearance.
What to do
Monitor disease response and consider an alternative antifungal; adjust bexarotene according to clinical response and lipid and thyroid monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Griseofulvin?
MediHelp rates the interaction as moderate. Bexarotene and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is metabolized by CYP3A4, and griseofulvin may lower its concentrations. This could reduce antitumor effect in cutaneous T-cell lymphoma.
How serious is the interaction between Bexarotene and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response and consider an alternative antifungal; adjust bexarotene according to clinical response and lipid and thyroid monitoring.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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