Drug interactions
Bexarotene + Hydrocortisone
Severity: Minor
Bexarotene and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolised by CYP3A4, and hydrocortisone may weakly induce this enzyme. The effect on bexarotene exposure is theoretical and likely small.
What this interaction means in plain words
Bexarotene and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bexarotene belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction increases bexarotene metabolism.
What to do
No routine adjustment is needed; monitor therapeutic response and lipid and thyroid parameters as usual for bexarotene.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Hydrocortisone?
MediHelp rates the interaction as minor. Bexarotene and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bexarotene is metabolised by CYP3A4, and hydrocortisone may weakly induce this enzyme. The effect on bexarotene exposure is theoretical and likely small.
How serious is the interaction between Bexarotene and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor therapeutic response and lipid and thyroid parameters as usual for bexarotene.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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