Drug interactions
Bexarotene + Isoniazid
Severity: Moderate
Bexarotene and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolized by CYP3A4, and isoniazid may weakly inhibit this enzyme, possibly raising bexarotene levels. Both can affect the liver, and bexarotene causes lipid abnormalities and hepatic enzyme elevations.
What this interaction means in plain words
Bexarotene and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Possible CYP3A4 inhibition by isoniazid plus additive hepatotoxicity.
What to do
Monitor liver tests and triglycerides, and watch for bexarotene toxicity. Reduce the bexarotene dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Isoniazid?
MediHelp rates the interaction as moderate. Bexarotene and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is metabolized by CYP3A4, and isoniazid may weakly inhibit this enzyme, possibly raising bexarotene levels. Both can affect the liver, and bexarotene causes lipid abnormalities and hepatic enzyme elevations.
How serious is the interaction between Bexarotene and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests and triglycerides, and watch for bexarotene toxicity. Reduce the bexarotene dose if adverse effects appear.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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