Drug interactions
Bexarotene + Vitamin a
Severity: Moderate
Bexarotene and Vitamin a: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is a retinoid, and adding vitamin A supplements can produce additive retinoid toxicity, including hypervitaminosis A symptoms, headache, liver injury and hypertriglyceridemia.
What this interaction means in plain words
Bexarotene and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Vitamin a belongs to Gastrointestinal Tract.
Why it happens
Additive retinoid receptor-mediated pharmacodynamic effects.
What to do
Avoid vitamin A supplements above the recommended daily intake during bexarotene therapy; monitor lipids and liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin a
- Acitretin + Vitamin a Major
- Etretinate + Vitamin a Major
- Isotretinoin + Vitamin a Major
- Palovarotene + Vitamin a Major
- Minocycline + Vitamin a Moderate
- Mipomersen + Vitamin a Moderate
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Vitamin a?
MediHelp rates the interaction as moderate. Bexarotene and Vitamin a can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is a retinoid, and adding vitamin A supplements can produce additive retinoid toxicity, including hypervitaminosis A symptoms, headache, liver injury and hypertriglyceridemia.
How serious is the interaction between Bexarotene and Vitamin a?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vitamin A supplements above the recommended daily intake during bexarotene therapy; monitor lipids and liver tests.
What other medicines interact with Vitamin a?
MediHelp also lists interactions of Vitamin a with, for example, Acitretin, Etretinate, Isotretinoin. The full list is on the Vitamin a page.
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