Drug interactions
Bictegravir + Empagliflozin-metformin
Severity: Moderate
Bictegravir and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir inhibits the renal transporters OCT2 and MATE1, which clear metformin, and raises metformin exposure. Higher levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Bictegravir and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OCT2 and MATE1 reduces renal tubular secretion of metformin.
What to do
Monitor glycemic control, renal function and signs of metformin toxicity. Consider limiting the metformin dose, particularly in patients with reduced eGFR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Frequently asked questions
Can I take Bictegravir with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Bictegravir and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir inhibits the renal transporters OCT2 and MATE1, which clear metformin, and raises metformin exposure. Higher levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially in renal impairment.
How serious is the interaction between Bictegravir and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control, renal function and signs of metformin toxicity. Consider limiting the metformin dose, particularly in patients with reduced eGFR.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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