Drug interactions
Bictegravir + Glipizide-metformin
Severity: Moderate
Bictegravir and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir raises metformin concentrations, increasing the risk of metformin adverse effects including lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Bictegravir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bictegravir inhibits OCT2 and MATE1, reducing renal tubular secretion of metformin.
What to do
Monitor glycemic control and renal function and limit the metformin dose as needed, using the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Bictegravir with Glipizide-metformin?
MediHelp rates the interaction as moderate. Bictegravir and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir raises metformin concentrations, increasing the risk of metformin adverse effects including lactic acidosis, especially in renal impairment.
How serious is the interaction between Bictegravir and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function and limit the metformin dose as needed, using the lowest effective dose.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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