Drug interactions
Bictegravir + Glyburide-metformin
Severity: Moderate
Bictegravir and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir raises metformin plasma concentrations, which can increase the risk of metformin adverse effects including lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Bictegravir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal tubular transporters OCT2 and MATE1 reduces metformin renal clearance.
What to do
Monitor glycemic control and metformin tolerability, and limit the metformin dose if exposure is excessive. Take extra care with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Bictegravir with Glyburide-metformin?
MediHelp rates the interaction as moderate. Bictegravir and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir raises metformin plasma concentrations, which can increase the risk of metformin adverse effects including lactic acidosis, especially with renal impairment.
How serious is the interaction between Bictegravir and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and metformin tolerability, and limit the metformin dose if exposure is excessive. Take extra care with reduced renal function.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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