Drug interactions
Bictegravir + Metformin-repaglinide
Severity: Moderate
Bictegravir and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bictegravir inhibits renal tubular transporters that eliminate metformin, raising metformin plasma concentrations. This increases the risk of metformin-related adverse effects, including lactic acidosis in susceptible patients.
What this interaction means in plain words
Bictegravir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OCT2 and MATE1 reduces renal tubular secretion of metformin.
What to do
Monitor glycemic control and renal function and limit or reduce the metformin dose as needed; this is particularly important in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Bictegravir with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Bictegravir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bictegravir inhibits renal tubular transporters that eliminate metformin, raising metformin plasma concentrations. This increases the risk of metformin-related adverse effects, including lactic acidosis in susceptible patients.
How serious is the interaction between Bictegravir and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function and limit or reduce the metformin dose as needed; this is particularly important in patients with renal impairment.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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