Drug interactions
Bismuth subsalicylate + Penbutolol
Severity: Minor
Bismuth subsalicylate and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylate absorbed from bismuth subsalicylate can inhibit renal prostaglandin synthesis, which may blunt the antihypertensive effect of beta-blockers. The effect is usually modest with short-term use.
What this interaction means in plain words
Bismuth subsalicylate and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate inhibition of prostaglandin synthesis reduces antihypertensive effect.
What to do
Limit bismuth subsalicylate to short courses and monitor blood pressure if used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Major
- Bismuth subsalicylate + Warfarin Major
- Acetylsalicylic acid + Bismuth subsalicylate Moderate
- Amlodipine-benazepril + Bismuth subsalicylate Moderate
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderate
- Aspirin rectal + Bismuth subsalicylate Moderate
Frequently asked questions
Can I take Bismuth subsalicylate with Penbutolol?
MediHelp rates the interaction as minor. Bismuth subsalicylate and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylate absorbed from bismuth subsalicylate can inhibit renal prostaglandin synthesis, which may blunt the antihypertensive effect of beta-blockers. The effect is usually modest with short-term use.
How serious is the interaction between Bismuth subsalicylate and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit bismuth subsalicylate to short courses and monitor blood pressure if used regularly.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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