Drug interactions
Bisoprolol + Candesartan
Severity: Moderate
Bisoprolol and Candesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they produce additive blood pressure lowering that may cause symptomatic hypotension, particularly at initiation. Candesartan is also fetotoxic in pregnancy.
What this interaction means in plain words
Bisoprolol and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Candesartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from beta-blockade and angiotensin II receptor blockade.
What to do
Monitor blood pressure and heart rate when starting or changing doses, and discontinue candesartan if pregnancy is detected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Bisoprolol with Candesartan?
MediHelp rates the interaction as moderate. Bisoprolol and Candesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together they produce additive blood pressure lowering that may cause symptomatic hypotension, particularly at initiation. Candesartan is also fetotoxic in pregnancy.
How serious is the interaction between Bisoprolol and Candesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses, and discontinue candesartan if pregnancy is detected.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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