Drug interactions
Bisoprolol + Eprosartan-hydrochlorothiazide
Severity: Moderate
Bisoprolol and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol adds to the blood pressure lowering of eprosartan and hydrochlorothiazide, and may cause bradycardia or hypotension. Effects on potassium are mixed, and thiazides can modestly affect glucose and lipid control.
What this interaction means in plain words
Bisoprolol and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects with opposing influences on serum potassium.
What to do
Monitor blood pressure, heart rate and serum potassium. Adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bisoprolol and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol adds to the blood pressure lowering of eprosartan and hydrochlorothiazide, and may cause bradycardia or hypotension. Effects on potassium are mixed, and thiazides can modestly affect glucose and lipid control.
How serious is the interaction between Bisoprolol and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium. Adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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