Drug interactions
Bisoprolol + Etrasimod
Severity: Moderate
Bisoprolol and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause transient heart rate reduction and AV conduction delay when started. Beta-blockers may add to bradycardia and AV block. Stable beta-blocker use did not show additive effects, but adding a beta-blocker to stable etrasimod is less well studied.
What this interaction means in plain words
Bisoprolol and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive negative chronotropic and dromotropic effects from S1P receptor modulation and beta-1 blockade.
What to do
Review baseline ECG and heart rate before starting etrasimod, and monitor heart rate. Take care when starting or increasing bisoprolol in a patient on etrasimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Bisoprolol with Etrasimod?
MediHelp rates the interaction as moderate. Bisoprolol and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can cause transient heart rate reduction and AV conduction delay when started. Beta-blockers may add to bradycardia and AV block. Stable beta-blocker use did not show additive effects, but adding a beta-blocker to stable etrasimod is less well studied.
How serious is the interaction between Bisoprolol and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and heart rate before starting etrasimod, and monitor heart rate. Take care when starting or increasing bisoprolol in a patient on etrasimod.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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