Drug interactions
Bisoprolol + Fluticasone-salmeterol
Severity: Moderate
Bisoprolol and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol, a cardioselective beta-blocker, can blunt the bronchodilator effect of salmeterol and may trigger bronchospasm at higher doses or in sensitive patients.
What this interaction means in plain words
Bisoprolol and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors, with selectivity lost at higher doses.
What to do
Use the lowest effective bisoprolol dose and monitor asthma or COPD control. Avoid in severe or unstable reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Bisoprolol and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol, a cardioselective beta-blocker, can blunt the bronchodilator effect of salmeterol and may trigger bronchospasm at higher doses or in sensitive patients.
How serious is the interaction between Bisoprolol and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bisoprolol dose and monitor asthma or COPD control. Avoid in severe or unstable reactive airway disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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