Drug interactions
Bisoprolol + Hydrochlorothiazide-valsartan
Severity: Minor
Bisoprolol and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol and valsartan with hydrochlorothiazide are often used together, with additive blood pressure reduction. Excessive hypotension or bradycardia can occur, while potassium changes are usually small and opposing.
What this interaction means in plain words
Bisoprolol and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bisoprolol belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamics with small opposing effects on potassium.
What to do
Monitor blood pressure, heart rate and potassium during initiation and dose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Bisoprolol and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bisoprolol and valsartan with hydrochlorothiazide are often used together, with additive blood pressure reduction. Excessive hypotension or bradycardia can occur, while potassium changes are usually small and opposing.
How serious is the interaction between Bisoprolol and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium during initiation and dose changes.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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