Drug interactions
Bisoprolol + Nifedipine
Severity: Moderate
Bisoprolol and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so combining them can cause excessive hypotension and reflex or additive effects on heart rate. The combination is commonly used deliberately, and the dihydropyridine nifedipine carries little risk of conduction block. In patients with poor left ventricular function, heart failure may be worsened.
What this interaction means in plain words
Bisoprolol and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through beta-1 blockade and calcium channel mediated vasodilation.
What to do
Monitor blood pressure and heart rate when starting or titrating either drug, and start with low doses. Watch for signs of heart failure in patients with reduced ejection fraction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Nifedipine
Frequently asked questions
Can I take Bisoprolol with Nifedipine?
MediHelp rates the interaction as moderate. Bisoprolol and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so combining them can cause excessive hypotension and reflex or additive effects on heart rate. The combination is commonly used deliberately, and the dihydropyridine nifedipine carries little risk of conduction block. In patients with poor left ventricular function, heart failure may be worsened.
How serious is the interaction between Bisoprolol and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating either drug, and start with low doses. Watch for signs of heart failure in patients with reduced ejection fraction.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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