Drug interactions
Bisoprolol + Sacubitril-valsartan
Severity: Minor
Bisoprolol and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol and sacubitril/valsartan are both standard heart failure therapies and are commonly combined. Together they can lower blood pressure and heart rate and cause dizziness, but this is usually manageable.
What this interaction means in plain words
Bisoprolol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bisoprolol belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through beta-blockade and angiotensin receptor and neprilysin inhibition.
What to do
Monitor blood pressure and heart rate during initiation and titration. Adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Bisoprolol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bisoprolol and sacubitril/valsartan are both standard heart failure therapies and are commonly combined. Together they can lower blood pressure and heart rate and cause dizziness, but this is usually manageable.
How serious is the interaction between Bisoprolol and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and titration. Adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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