Drug interactions
Bisoprolol + Salbutamol
Severity: Moderate
Bisoprolol and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol may reduce the response to salbutamol and can provoke bronchospasm in patients with reactive airway disease, especially at higher doses when its selectivity is lost.
What this interaction means in plain words
Bisoprolol and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Salbutamol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta adrenoceptors.
What to do
Use the lowest effective bisoprolol dose in patients with obstructive airway disease and monitor lung function and salbutamol response; consider a non-beta-blocker alternative in significant asthma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Salbutamol?
MediHelp rates the interaction as moderate. Bisoprolol and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol may reduce the response to salbutamol and can provoke bronchospasm in patients with reactive airway disease, especially at higher doses when its selectivity is lost.
How serious is the interaction between Bisoprolol and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bisoprolol dose in patients with obstructive airway disease and monitor lung function and salbutamol response; consider a non-beta-blocker alternative in significant asthma.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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