Drug interactions
Bisoprolol + Salmeterol
Severity: Moderate
Bisoprolol and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol is a beta-1 selective blocker that may reduce the bronchodilator effect of salmeterol. At higher doses selectivity is lost and bronchospasm can occur in patients with reactive airway disease.
What this interaction means in plain words
Bisoprolol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors.
What to do
Monitor respiratory symptoms and keep the bisoprolol dose low. Reassess the need for beta-blockade if asthma control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Salmeterol?
MediHelp rates the interaction as moderate. Bisoprolol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol is a beta-1 selective blocker that may reduce the bronchodilator effect of salmeterol. At higher doses selectivity is lost and bronchospasm can occur in patients with reactive airway disease.
How serious is the interaction between Bisoprolol and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and keep the bisoprolol dose low. Reassess the need for beta-blockade if asthma control worsens.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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