Drug interactions
Bisoprolol + Terazosin
Severity: Moderate
Bisoprolol and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-1 blocker with a beta-blocker produces additive blood pressure lowering. Orthostatic hypotension and dizziness can occur, particularly after the first terazosin dose or a dose increase. This combination is often used deliberately but needs attention to postural symptoms.
What this interaction means in plain words
Bisoprolol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotension from alpha-1 mediated vasodilation plus beta-blockade, with blunted reflex tachycardia.
What to do
Start terazosin at a low dose at bedtime and titrate gradually, and check standing and sitting blood pressure after initiation or dose changes. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Terazosin?
MediHelp rates the interaction as moderate. Bisoprolol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-1 blocker with a beta-blocker produces additive blood pressure lowering. Orthostatic hypotension and dizziness can occur, particularly after the first terazosin dose or a dose increase. This combination is often used deliberately but needs attention to postural symptoms.
How serious is the interaction between Bisoprolol and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start terazosin at a low dose at bedtime and titrate gradually, and check standing and sitting blood pressure after initiation or dose changes. Counsel patients to rise slowly.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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