Drug interactions
Bisoprolol + Timolol
Severity: Moderate
Bisoprolol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining bisoprolol with timolol duplicates beta-blockade, and ophthalmic timolol can still reach the systemic circulation. This may add to bradycardia, hypotension and AV block, and nonselective blockade can worsen bronchospasm.
What this interaction means in plain words
Bisoprolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic receptor blockade.
What to do
Avoid oral duplication. With timolol eye drops, monitor heart rate and blood pressure, or use a non-beta-blocker glaucoma drug if bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Bisoprolol with Timolol?
MediHelp rates the interaction as moderate. Bisoprolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining bisoprolol with timolol duplicates beta-blockade, and ophthalmic timolol can still reach the systemic circulation. This may add to bradycardia, hypotension and AV block, and nonselective blockade can worsen bronchospasm.
How serious is the interaction between Bisoprolol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral duplication. With timolol eye drops, monitor heart rate and blood pressure, or use a non-beta-blocker glaucoma drug if bradycardia develops.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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