Drug interactions
Bisoprolol + Valsartan
Severity: Moderate
Bisoprolol and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs have additive blood pressure lowering, commonly used therapeutically in hypertension and heart failure, but hypotension can occur at initiation. Valsartan may increase potassium, and it is fetotoxic in pregnancy.
What this interaction means in plain words
Bisoprolol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects from angiotensin receptor blockade and beta-blockade; ARB-related reduction in aldosterone can raise potassium.
What to do
Monitor blood pressure, potassium and renal function after initiation and dose changes. Avoid in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Bisoprolol with Valsartan?
MediHelp rates the interaction as moderate. Bisoprolol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs have additive blood pressure lowering, commonly used therapeutically in hypertension and heart failure, but hypotension can occur at initiation. Valsartan may increase potassium, and it is fetotoxic in pregnancy.
How serious is the interaction between Bisoprolol and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function after initiation and dose changes. Avoid in pregnancy.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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