Drug interactions
Bitter melon + Hydrochlorothiazide-valsartan
Severity: Minor
Bitter melon and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bitter melon has glucose-lowering and possible mild diuretic effects, and case reports link it with electrolyte disturbances. Combined with hydrochlorothiazide, additive potassium loss is theoretically possible.
What this interaction means in plain words
Bitter melon and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive potassium loss; the mechanism is not well established.
What to do
Monitor serum potassium and blood pressure in patients who use bitter melon regularly with this combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Bitter melon with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Bitter melon and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bitter melon has glucose-lowering and possible mild diuretic effects, and case reports link it with electrolyte disturbances. Combined with hydrochlorothiazide, additive potassium loss is theoretically possible.
How serious is the interaction between Bitter melon and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure in patients who use bitter melon regularly with this combination.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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