Drug interactions
Bivalirudin + Cefuroxime
Severity: Minor
Bivalirudin and Cefuroxime: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins rarely impair coagulation, but cefuroxime has little effect on hemostasis. Bivalirudin is a direct thrombin inhibitor, and any additive bleeding effect with cefuroxime would be small and is not well documented.
What this interaction means in plain words
Bivalirudin and Cefuroxime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effect on hemostasis; cefuroxime is not a recognized cause of hypoprothrombinemia, so the mechanism is not established.
What to do
No change in therapy is needed. Monitor for bleeding and coagulation parameters as usual during bivalirudin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bivalirudin and Cefuroxime, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Frequently asked questions
Can I take Bivalirudin with Cefuroxime?
MediHelp rates the interaction as minor. Bivalirudin and Cefuroxime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalosporins rarely impair coagulation, but cefuroxime has little effect on hemostasis. Bivalirudin is a direct thrombin inhibitor, and any additive bleeding effect with cefuroxime would be small and is not well documented.
How serious is the interaction between Bivalirudin and Cefuroxime?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in therapy is needed. Monitor for bleeding and coagulation parameters as usual during bivalirudin use.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
