Drug interactions
Aluminum hydroxide + Cefuroxime
Severity: Moderate
Aluminum hydroxide and Cefuroxime: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Raising gastric pH with antacids lowers the bioavailability of oral cefuroxime axetil. Reduced exposure may cause treatment failure in infections.
What this interaction means in plain words
Aluminum hydroxide and Cefuroxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Cefuroxime belongs to Anti Bacterial.
Why it happens
Elevated gastric pH reduces dissolution and absorption of cefuroxime axetil.
What to do
Separate cefuroxime axetil from the antacid by at least 2 hours, giving cefuroxime with food. Monitor clinical response if acid-reducing therapy is continuous.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Cefuroxime
- Amikacin + Cefuroxime Moderate
Frequently asked questions
Can I take Aluminum hydroxide with Cefuroxime?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Cefuroxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Raising gastric pH with antacids lowers the bioavailability of oral cefuroxime axetil. Reduced exposure may cause treatment failure in infections.
How serious is the interaction between Aluminum hydroxide and Cefuroxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate cefuroxime axetil from the antacid by at least 2 hours, giving cefuroxime with food. Monitor clinical response if acid-reducing therapy is continuous.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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