Drug interactions
Bivalirudin + Cyclophosphamide
Severity: Moderate
Bivalirudin and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide can cause thrombocytopenia, which raises bleeding risk when an anticoagulant such as bivalirudin is given. The combination can lead to more bleeding than the anticoagulant alone, especially during procedures.
What this interaction means in plain words
Bivalirudin and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic additive bleeding risk from chemotherapy-induced thrombocytopenia and direct thrombin inhibition.
What to do
Check platelet count before and during bivalirudin therapy and monitor for bleeding. Adjust or withhold anticoagulation if platelets fall markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Bivalirudin with Cyclophosphamide?
MediHelp rates the interaction as moderate. Bivalirudin and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide can cause thrombocytopenia, which raises bleeding risk when an anticoagulant such as bivalirudin is given. The combination can lead to more bleeding than the anticoagulant alone, especially during procedures.
How serious is the interaction between Bivalirudin and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check platelet count before and during bivalirudin therapy and monitor for bleeding. Adjust or withhold anticoagulation if platelets fall markedly.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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