Drug interactions
Bivalirudin + Dipyridamole
Severity: Moderate
Bivalirudin and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole's antiplatelet effect adds to bivalirudin's direct thrombin inhibition, which may increase bleeding risk modestly.
What this interaction means in plain words
Bivalirudin and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effect of platelet inhibition and direct thrombin inhibition.
What to do
Monitor ACT or aPTT, hemoglobin and bleeding signs during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Frequently asked questions
Can I take Bivalirudin with Dipyridamole?
MediHelp rates the interaction as moderate. Bivalirudin and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole's antiplatelet effect adds to bivalirudin's direct thrombin inhibition, which may increase bleeding risk modestly.
How serious is the interaction between Bivalirudin and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ACT or aPTT, hemoglobin and bleeding signs during combined use.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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