Drug interactions
Bivalirudin + Flurbiprofen
Severity: Moderate
Bivalirudin and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor and flurbiprofen impairs platelet function and can injure the gastric mucosa. Together the bleeding risk is higher than with either drug alone.
What this interaction means in plain words
Bivalirudin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment from direct thrombin inhibition and NSAID antiplatelet effect.
What to do
Monitor for bleeding during and after bivalirudin therapy; avoid starting NSAIDs around procedures unless needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Bivalirudin with Flurbiprofen?
MediHelp rates the interaction as moderate. Bivalirudin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor and flurbiprofen impairs platelet function and can injure the gastric mucosa. Together the bleeding risk is higher than with either drug alone.
How serious is the interaction between Bivalirudin and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding during and after bivalirudin therapy; avoid starting NSAIDs around procedures unless needed.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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