Drug interactions
Bivalirudin + Ibuprofen
Severity: Moderate
Bivalirudin and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and ibuprofen impairs platelet function and can cause GI bleeding. Together they increase the risk of hemorrhage.
What this interaction means in plain words
Bivalirudin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: direct thrombin inhibition plus NSAID platelet inhibition.
What to do
Monitor for signs of bleeding and hemoglobin, and avoid ibuprofen in patients at high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Bivalirudin with Ibuprofen?
MediHelp rates the interaction as moderate. Bivalirudin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and ibuprofen impairs platelet function and can cause GI bleeding. Together they increase the risk of hemorrhage.
How serious is the interaction between Bivalirudin and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and hemoglobin, and avoid ibuprofen in patients at high bleeding risk.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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