Drug interactions
Bivalirudin + Naproxen
Severity: Moderate
Bivalirudin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor and naproxen inhibits platelet function and can cause GI lesions. Combined use increases the likelihood of bleeding.
What this interaction means in plain words
Bivalirudin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of direct thrombin inhibition and NSAID-mediated platelet inhibition.
What to do
Avoid starting or continuing NSAIDs around bivalirudin therapy unless essential. Monitor for bleeding and hemoglobin if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Bivalirudin with Naproxen?
MediHelp rates the interaction as moderate. Bivalirudin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor and naproxen inhibits platelet function and can cause GI lesions. Combined use increases the likelihood of bleeding.
How serious is the interaction between Bivalirudin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting or continuing NSAIDs around bivalirudin therapy unless essential. Monitor for bleeding and hemoglobin if used together.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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