Drug interactions
Bivalirudin + Tolmetin
Severity: Moderate
Bivalirudin and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor and tolmetin impairs platelet aggregation and can injure the gastric mucosa. Combined use increases the likelihood of bleeding.
What this interaction means in plain words
Bivalirudin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from direct thrombin inhibition and NSAID-induced platelet dysfunction.
What to do
Avoid starting NSAIDs around bivalirudin procedures unless essential. Monitor for bleeding and haemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Bivalirudin with Tolmetin?
MediHelp rates the interaction as moderate. Bivalirudin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor and tolmetin impairs platelet aggregation and can injure the gastric mucosa. Combined use increases the likelihood of bleeding.
How serious is the interaction between Bivalirudin and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting NSAIDs around bivalirudin procedures unless essential. Monitor for bleeding and haemoglobin.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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