Drug interactions
Bretylium + Eprosartan
Severity: Moderate
Bretylium and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium can cause marked hypotension by blocking adrenergic neuron release of norepinephrine, and eprosartan adds to the blood pressure lowering effect. The combination may produce symptomatic or severe hypotension.
What this interaction means in plain words
Bretylium and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects via sympathetic neuron blockade and angiotensin II receptor blockade.
What to do
Monitor blood pressure closely and consider reducing or holding eprosartan during bretylium therapy. Correct volume depletion beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Bretylium with Eprosartan?
MediHelp rates the interaction as moderate. Bretylium and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium can cause marked hypotension by blocking adrenergic neuron release of norepinephrine, and eprosartan adds to the blood pressure lowering effect. The combination may produce symptomatic or severe hypotension.
How serious is the interaction between Bretylium and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider reducing or holding eprosartan during bretylium therapy. Correct volume depletion beforehand.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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