Drug interactions
Bretylium + Fosinopril
Severity: Moderate
Bretylium and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension through adrenergic neuron blockade, and fosinopril adds further blood pressure lowering. The combination may produce pronounced or symptomatic hypotension.
What this interaction means in plain words
Bretylium and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects of adrenergic neuron blockade and ACE inhibition.
What to do
Monitor blood pressure closely during bretylium therapy and reduce or hold fosinopril if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Bretylium with Fosinopril?
MediHelp rates the interaction as moderate. Bretylium and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension through adrenergic neuron blockade, and fosinopril adds further blood pressure lowering. The combination may produce pronounced or symptomatic hypotension.
How serious is the interaction between Bretylium and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during bretylium therapy and reduce or hold fosinopril if hypotension occurs.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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